nerve damage tobacco Direct and Indirect (via nNOS) Sympathomimetic Effects of Nicotine From Commonly Used Drugs - Tobacco/Nicotine

While this study was not designed to evaluate the mechanism, it seems to suggest that epigenetic changes could play a role, with reactive oxygen species appearing to be a key contributor that creates the primary source of damage, followed by secondary contributors

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Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1alpha mediated attenuation of mitochondrial oxidative stress

This is the case even if you don't use marijuana a lot

When you think about ancient artifacts, you likely picture some kind of golden idol, maybe hidden far away in a booby-trapped temple